PDB entry 2qoo

View 2qoo on RCSB PDB site
Description: Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant
Class: transferase
Keywords: receptor tyrosine kinase, juxtamembrane segment, structural genomics, mutant, Structural Genomics Consortium, SGC, ATP-binding, Nucleotide-binding, Phosphorylation, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-07-20, released 2007-08-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: 0.19
AEROSPACI score: 0.77 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ephrin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P4R6
      • engineered (21)
      • engineered (167)
    Domains in SCOPe 2.06: d2qooa_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qooA (A:)
gsdekrlhfgnghlklpglrtfvdphtfedptqtvhefakeldatnisidkvvgagefge
vcsgrlklpskkeisvaiktlkvgytekqrrdflgeasimgqfdhpniirlegvvtkskp
vmivteymengsldsflrkhdaqftviqlvgmlrgiasgmkylsdmgfvhrdlaarnili
nsnlvckvsdfglsrvleddpeaayttrggkipirwtspeaiayrkftsasdvwsygivl
wevmsygerpywemsnqdvikavdegyrlpppmdcpaalyqlmldcwqkdrnnrpkfeqi
vsildklirnpgslkiitsaaarpsnllldqsnvdittfrttgdwlngvwtahckeiftg
veysscdtiakis

    Sequence, based on observed residues (ATOM records): (download) 
    >2qooA (A:)
tfvdpvhefakeldatnisidkvvgagefgevcsgrlklpskkeisvaiktlkvgytekq
rrdflgeasimgqfdhpniirlegvvtkskpvmivteymengsldsflrkhdaqftviql
vgmlrgiasgmkylsdmgfvhrdlaarnilinsnlvckvsdfpirwtspeaiayrkftsa
sdvwsygivlwevmsygerpywemsnqdvikavdegyrlpppmdcpaalyqlmldcwqkd
rnnrpkfeqivsildklirnpgslkiitnllld