PDB entry 2qlq

View 2qlq on RCSB PDB site
Description: Crystal structure of SRC kinase domain with covalent inhibitor RL3
Class: transferase
Keywords: Src kinase domain, drug resistance, irreversible inhibitor, kovalent inhibitor, Alternative splicing, ATP-binding, Lipoprotein, Myristate, Nucleotide-binding, Phosphorylation, Proto-oncogene, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase
Deposited on 2007-07-13, released 2008-03-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-03-03, with a file datestamp of 2009-02-27.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: 0.215
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered (97)
    Domains in SCOPe 2.06: d2qlqa_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered (97)
    Domains in SCOPe 2.06: d2qlqb_
  • Heterogens: SR2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qlqA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qlqA (A:)
akdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlaqvmkklrheklvqlyav
vsepiyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlra
anilvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvn
revldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyq
pgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qlqB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2qlqB (B:)
kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlqvmkklrheklvqlyavvs
eepiyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraa
nilvgenlvckvadfglarpikwtapeaalygrftiksdvwsfgilltelttkgrvpypg
mvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstep
qyqpgenl