PDB entry 2qjb

View 2qjb on RCSB PDB site
Description: Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB
Class: Cytokine/Receptor
Keywords: ligand-receptor complex, Chondrogenesis, Cleavage on pair of basic residues, Cytokine, Developmental protein, Differentiation, Glycoprotein, Growth factor, Osteogenesis, ATP-binding, Disease mutation, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Phosphorylation, Serine/threonine-protein kinase, Transferase, Transmembrane, Cytokine-Receptor COMPLEX
Deposited on 2007-07-06, released 2008-01-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.207
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2qjba_
  • Chain 'B':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2qjbb_
  • Chain 'C':
    Compound: Bone morphogenetic protein receptor type IA
    Species: Homo sapiens [TaxId:9606]
    Gene: BMPR1A, ACVRLK3, ALK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36894
      • engineered (47)
      • engineered (51)
      • engineered (66-67)
      • engineered (79)
      • engineered (83-85)
      • engineered (93)
      • engineered (95)
      • engineered (97-100)
      • engineered (103)
    Domains in SCOPe 2.06: d2qjbc_
  • Chain 'D':
    Compound: Bone morphogenetic protein receptor type IA
    Species: Homo sapiens [TaxId:9606]
    Gene: BMPR1A, ACVRLK3, ALK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36894
      • engineered (47)
      • engineered (51)
      • engineered (66-67)
      • engineered (79)
      • engineered (83-85)
      • engineered (93)
      • engineered (95)
      • engineered (97-100)
      • engineered (103)
    Domains in SCOPe 2.06: d2qjbd_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qjbA (A:)
maqakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnst
nhaivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjbA (A:)
ssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsvn
skipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qjbB (B:)
maqakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnst
nhaivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjbB (B:)
kssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsv
nskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2qjbC (C:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycshhcpedainntci
tnghcftmieeddqgettltsgclglegsdfqcrdtpiphqrrsieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjbC (C:)
tlpflkcycshhcpedainntcitnghcftmieeddqgettltsgclglegsdfqcrdtp
iphqrrsieccrtnlcnqylqptlp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2qjbD (D:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycshhcpedainntci
tnghcftmieeddqgettltsgclglegsdfqcrdtpiphqrrsieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjbD (D:)
tlpflkcycshhcpedainntcitnghcftmieeddqgettltsgclglegsdfqcrdtp
iphqrrsieccrtnlcnqylqptlppvvig