PDB entry 2qja

View 2qja on RCSB PDB site
Description: Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12
Class: Cytokine/Receptor
Keywords: ligand-receptor complex, Chondrogenesis, Cleavage on pair of basic residues, Cytokine, Developmental protein, Differentiation, Glycoprotein, Growth factor, Osteogenesis, ATP-binding, Disease mutation, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Phosphorylation, Serine/threonine-protein kinase, Transferase, Transmembrane, Cytokine-Receptor COMPLEX
Deposited on 2007-07-06, released 2008-01-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.216
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2qjaa_
  • Chain 'B':
    Compound: Bone morphogenetic protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BMP2, BMP2A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2qjab_
  • Chain 'C':
    Compound: Bone morphogenetic protein receptor type IA
    Species: Homo sapiens [TaxId:9606]
    Gene: BMPR1A, ACVRLK3, ALK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36894
      • engineered (79)
      • engineered (83-85)
      • engineered (93)
      • engineered (95)
      • engineered (97-100)
      • engineered (103)
    Domains in SCOPe 2.05: d2qjac_
  • Chain 'D':
    Compound: Bone morphogenetic protein receptor type IA
    Species: Homo sapiens [TaxId:9606]
    Gene: BMPR1A, ACVRLK3, ALK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36894
      • engineered (79)
      • engineered (83-85)
      • engineered (93)
      • engineered (95)
      • engineered (97-100)
      • engineered (103)
    Domains in SCOPe 2.05: d2qjad_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qjaA (A:)
maqakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnst
nhaivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjaA (A:)
kssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsv
nskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qjaB (B:)
maqakhkqrkrlkssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnst
nhaivqtlvnsvnskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjaB (B:)
kssckrhplyvdfsdvgwndwivappgyhafychgecpfpladhlnstnhaivqtlvnsv
nskipkaccvptelsaismlyldenekvvlknyqdmvvegcgcr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2qjaC (C:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
tnghcfaiieeddqgettltsgclglegsdfqcrdtpiphqrrsieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjaC (C:)
tlpflkcycsghcpddainntcitnghcfaiieeddqgettltsgclglegsdfqcrdtp
iphqrrsieccrtnlcnqylqptlp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2qjaD (D:)
gsgamaqnldsmlhgtgmksdsdqkksengvtlapedtlpflkcycsghcpddainntci
tnghcfaiieeddqgettltsgclglegsdfqcrdtpiphqrrsieccrtnlcnqylqpt
lppvvigpffdgsir

    Sequence, based on observed residues (ATOM records): (download) 
    >2qjaD (D:)
dtlpflkcycsghcpddainntcitnghcfaiieeddqgettltsgclglegsdfqcrdt
piphqrrsieccrtnlcnqylqptlppvvigpf