PDB entry 2qdm

View 2qdm on RCSB PDB site
Description: Crystal structure of the HePTP catalytic domain C270S/D236A/Q314A mutant
Class: hydrolase
Keywords: HePTP, HUMAN HEMATOPOIETIC TYROSINE PHOSPHATASE CATALYTIC DOMAIN MUTANT, LC-PTP, PTPN7, HYDROLASE
Deposited on 2007-06-21, released 2008-06-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.166
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 7
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35236
      • engineered (205)
      • engineered (239)
      • engineered (283)
    Domains in SCOPe 2.05: d2qdma_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qdmA (A:)
mgsdkihhhhhhmntprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvsp
edldipghaskdryktilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgp
mpntvsdfwemvwqeevslivmltqlregkekcvhywpteeetygpfqiriqdmkecpey
tvrqltiqyqeerrsvkhilfsawpahqtpesagpllrlvaeveespetaahpgpivvhs
sagigrtgcfiatrigcqqlkargevdilgivcqlrldrggmiataeqyqflhhtlalya
gqlpeepsp

    Sequence, based on observed residues (ATOM records): (download) 
    >2qdmA (A:)
tprevtlhflrtaghpltrwalqrqppspkqleeeflkipsnfvspedldipghaskdry
ktilpnpqsrvclgraqsqedgdyinanyirgydgkekvyiatqgpmpntvsdfwemvwq
eevslivmltqlcvhywpteeetygpfqiriqdmkecpeytvrqltiqyqeerrsvkhil
fsawpahqtpesagpllrlvaeveespetaahpgpivvhssagigrtgcfiatrigcqql
kargevdilgivcqlrldrggmiataeqyqflhhtlalyagqlpee