PDB entry 2qb4

View 2qb4 on RCSB PDB site
Description: Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine
Class: transport protein
Keywords: membrane protein, neurotransmitter sodium symporter, occluded, secondary amine tricyclic antidepressant, dibenzazepine , Transmembrane, Transport, TRANSPORT PROTEIN
Deposited on 2007-06-15, released 2007-08-21
The last revision prior to the SCOP 1.75 freeze date was dated 2008-01-08, with a file datestamp of 2008-01-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.201
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transporter
    Species: Aquifex aeolicus
    Gene: snf
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (Start-512)
      • cloning artifact (513-515)
    Domains in SCOP 1.75: d2qb4a1
  • Heterogens: BOG, NA, LEU, DSM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2qb4A (A:)
    mevkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmw
    iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
    kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
    silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
    pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisip
    aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaim
    qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
    iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
    wtvwitrfyiiglflfltflvflaerrrnhesagtlvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2qb4A (A:)
    rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
    mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
    glvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
    iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
    avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaff
    gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiaf
    ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
    fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwit
    rfyiiglflfltflvflaerrrnhesagtl