PDB entry 2q8i
View 2q8i on RCSB PDB site
Description: Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
Class: transferase
Keywords: GHKL ATPase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, radicicol, TRANSFERASE
Deposited on
2007-06-10, released
2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-18, with a file datestamp of
2017-10-13.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3
Species: Homo sapiens [TaxId:9606]
Gene: PDK3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2q8ia1, d2q8ia3 - Chain 'B':
Compound: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Species: Homo sapiens [TaxId:9606]
Gene: DLAT, DLTA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2q8ib_ - Heterogens: K, RDC, GOL, RED, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2q8iA (A:)
ggshhhhhhgmarlenlyfqgkqpvpkqierysrfspsplsikqfldfgrdnacektsym
flrkelpvrlantmrevnllpdnllnrpsvglvqswymqsflelleyenkspedpqvldn
flqvlikvrnrhndvvptmaqgvieykekfgfdpfistniqyfldrfytnrisfrmlinq
htllfggdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnaka
pdkpiqvvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisd
lgggvplrkidrlfnymystaprpsleptraaplagfgyglpisrlyaryfqgdlklysm
egvgtdaviylkalssesferlpvfnksawrhykttpeaddwsnpsseprdaskykakq
Sequence, based on observed residues (ATOM records): (download)
>2q8iA (A:)
pkqierysrfspsplsikqfldfgrdnacektsymflrkelpvrlantmrevnllpdnll
nrpsvglvqswymqsflelleyenkspedpqvldnflqvlikvrnrhndvvptmaqgvie
ykekfgfdpfistniqyfldrfytnrisfrmlinqhtllfgtnpvhpkhigsidptcnva
dvvkdayetakmlceqyylvapeleveefnakapdkpiqvvyvpshlfhmlfelfknsmr
atvelyedrkegypavktlvtlgkedlsikisdlgggvplrkidrlfnymysgyglpisr
lyaryfqgdlklysmegvgtdaviylkalssesferlpvfnksawrhykttpeaddwsnp
sseprdask
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2q8iB (B:)
ggshhhhhhgmarlenlyfqgssypphmqvllpalsptmtmgtvqrwekkvgeklsegdl
laeietdkatigfevqeegylakilvpegtrdvplgtplciivekeadisafadyrptev
tdlkpqvp
Sequence, based on observed residues (ATOM records): (download)
>2q8iB (B:)
sypphmqvllpalsptmtmgtvqrwekkvgeklsegdllaeietdkatigfevqeegyla
kilvpegtrdvplgtplciivekeadisafady