PDB entry 2q8i

View 2q8i on RCSB PDB site
Description: Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol
Class: transferase
Keywords: GHKL ATPase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, radicicol, TRANSFERASE
Deposited on 2007-06-10, released 2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2q8ia1, d2q8ia3
  • Chain 'B':
    Compound: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
    Species: Homo sapiens [TaxId:9606]
    Gene: DLAT, DLTA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2q8ib_
  • Heterogens: K, RDC, GOL, RED, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2q8iA (A:)
    ggshhhhhhgmarlenlyfqgkqpvpkqierysrfspsplsikqfldfgrdnacektsym
    flrkelpvrlantmrevnllpdnllnrpsvglvqswymqsflelleyenkspedpqvldn
    flqvlikvrnrhndvvptmaqgvieykekfgfdpfistniqyfldrfytnrisfrmlinq
    htllfggdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnaka
    pdkpiqvvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisd
    lgggvplrkidrlfnymystaprpsleptraaplagfgyglpisrlyaryfqgdlklysm
    egvgtdaviylkalssesferlpvfnksawrhykttpeaddwsnpsseprdaskykakq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2q8iA (A:)
    pkqierysrfspsplsikqfldfgrdnacektsymflrkelpvrlantmrevnllpdnll
    nrpsvglvqswymqsflelleyenkspedpqvldnflqvlikvrnrhndvvptmaqgvie
    ykekfgfdpfistniqyfldrfytnrisfrmlinqhtllfgtnpvhpkhigsidptcnva
    dvvkdayetakmlceqyylvapeleveefnakapdkpiqvvyvpshlfhmlfelfknsmr
    atvelyedrkegypavktlvtlgkedlsikisdlgggvplrkidrlfnymysgyglpisr
    lyaryfqgdlklysmegvgtdaviylkalssesferlpvfnksawrhykttpeaddwsnp
    sseprdask
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2q8iB (B:)
    ggshhhhhhgmarlenlyfqgssypphmqvllpalsptmtmgtvqrwekkvgeklsegdl
    laeietdkatigfevqeegylakilvpegtrdvplgtplciivekeadisafadyrptev
    tdlkpqvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >2q8iB (B:)
    sypphmqvllpalsptmtmgtvqrwekkvgeklsegdllaeietdkatigfevqeegyla
    kilvpegtrdvplgtplciivekeadisafady