PDB entry 2q8h

View 2q8h on RCSB PDB site
Description: Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA)
Class: transferase
Keywords: GHKL ATPase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, dichroloacetate, TRANSFERASE
Deposited on 2007-06-10, released 2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2q8ha1, d2q8ha2
  • Heterogens: K, TF4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2q8hA (A:)
sdsgsspasergvpgqvdfyarfspsplsmkqfldfgsvnacektsfmflrqelpvrlan
imkeisllpdnllrtpsvqlvqswyiqslqelldfkdksaedakaiydftdtvirirnrh
ndviptmaqgvieykesfgvdpvtsqnvqyfldrfymsrisirmllnqhsllfggkgkgs
pshrkhigsinpncnvlevikdgyenarrlcdlyyinspeleleelnakspgqpiqvvyv
pshlyhmvfelfknamratmehhanrgvyppiqvhvtlgnedltvkmsdrgggvplrkid
rlfnymystaprprvetsravplagfgyglpisrlyaqyfqgdlklyslegygtdaviyi
kalstdsierlpvynkaawkhyntnheaddwcvpsrepkdmttfrsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2q8hA (A:)
gvpgqvdfyarfspsplsmkqfldfgscektsfmflrqelpvrlanimkeisllpdnllr
tpsvqlvqswyiqslqelldfkdksaedakaiydftdtvirirnrhndviptmaqgviey
kesfdpvtsqnvqyfldrfymsrisirmllnqhsllfghigsinpncnvlevikdgyena
rrlcdlyyinspeleleelnakspgqpiqvvyvpshlyhmvfelfknamratmehhanrg
vyppiqvhvtlgnedltvkmsdrgggvplrkidrlfnymystaprprvetsravplagfg
yglpisrlyaqyfqgdlklyslegygtdaviyikalstdsierlpvynkaawkhyntnad
dwcvp