PDB entry 2q8g

View 2q8g on RCSB PDB site
Description: Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545
Class: transferase
Keywords: GHKL ATPase/kinase family, pyruvate dehydrogenase complex, mitochondrial kinase, glucose-lowering drug AZD7545, TRANSFERASE
Deposited on 2007-06-10, released 2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2q8ga1, d2q8ga2
  • Heterogens: K, AZX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2q8gA (A:)
sdsgsspasergvpgqvdfyarfspsplsmkqfldfgsvnacektsfmflrqelpvrlan
imkeisllpdnllrtpsvqlvqswyiqslqelldfkdksaedakaiydftdtvirirnrh
ndviptmaqgvieykesfgvdpvtsqnvqyfldrfymsrisirmllnqhsllfggkgkgs
pshrkhigsinpncnvlevikdgyenarrlcdlyyinspeleleelnakspgqpiqvvyv
pshlyhmvfelfknamratmehhanrgvyppiqvhvtlgnedltvkmsdrgggvplrkid
rlfnymystaprprvetsravplagfgyglpisrlyaqyfqgdlklyslegygtdaviyi
kalstdsierlpvynkaawkhyntnheaddwcvpsrepkdmttfrsa

    Sequence, based on observed residues (ATOM records): (download) 
    >2q8gA (A:)
gvpgqvdfyarfspsplsmkqfldfgsvnacektsfmflrqelpvrlanimkeisllpdn
llrtpsvqlvqswyiqslqelldfkdksaedakaiydftdtvirirnrhndviptmaqgv
ieykesfdpvtsqnvqyfldrfymsrisirmllnqhsllfgkhigsinpncnvlevikdg
yenarrlcdlyyinspeleleelnakspgqpiqvvyvpshlyhmvfelfknamratmehh
anrgvyppiqvhvtlgnedltvkmsdrgggvplrkidrlfnymystaprprvetsravpl
agfgyglpisrlyaqyfqgdlklyslegygtdaviyikalstdsierlpvynkaawkhyn
tnddwcvp