PDB entry 2q7r

View 2q7r on RCSB PDB site
Description: Crystal structure of human FLAP with an iodinated analog of MK-591
Class: membrane protein, lipid transport
Keywords: FLAP, MAPEG, membrane protein, LIPID TRANSPORT
Deposited on 2007-06-07, released 2007-08-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 4 Å
R-factor: 0.268
AEROSPACI score: 0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
    Domains in SCOPe 2.07: d2q7ra1
  • Chain 'B':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
      • engineered (147)
    Domains in SCOPe 2.07: d2q7rb1
  • Chain 'C':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
      • engineered (147)
    Domains in SCOPe 2.07: d2q7rc1
  • Chain 'D':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
      • engineered (147)
    Domains in SCOPe 2.07: d2q7rd1
  • Chain 'E':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
    Domains in SCOPe 2.07: d2q7re1
  • Chain 'F':
    Compound: Arachidonate 5-lipoxygenase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ALOX5AP, FLAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20292 (0-End)
      • modified residue (0)
      • modified residue (88)
      • modified residue (124)
      • engineered (147)
    Domains in SCOPe 2.07: d2q7rf1
  • Heterogens: 3CS

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2q7rA (A:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rA (A:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2q7rB (B:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rB (B:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyia

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2q7rC (C:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rC (C:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiat

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2q7rD (D:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rD (D:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyia

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2q7rE (E:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rE (E:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2q7rF (F:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7rF (F:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiat