PDB entry 2q7r
View 2q7r on RCSB PDB site
Description: Crystal structure of human FLAP with an iodinated analog of MK-591
Class: membrane protein, lipid transport
Keywords: FLAP, MAPEG, membrane protein, MEMBRANE PROTEIN, LIPID TRANSPORT
Deposited on
2007-06-07, released
2007-08-21
The last revision prior to the SCOP 1.75 freeze date was dated
2007-08-21, with a file datestamp of
2007-08-17.
Experiment type: XRAY
Resolution: 4 Å
R-factor: 0.268
AEROSPACI score: -0.04
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
Domains in SCOP 1.75: d2q7ra1 - Chain 'B':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
- engineered (147)
Domains in SCOP 1.75: d2q7rb1 - Chain 'C':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
- engineered (147)
Domains in SCOP 1.75: d2q7rc1 - Chain 'D':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
- engineered (147)
Domains in SCOP 1.75: d2q7rd1 - Chain 'E':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
Domains in SCOP 1.75: d2q7re1 - Chain 'F':
Compound: Arachidonate 5-lipoxygenase-activating protein
Species: HOMO SAPIENS
Gene: ALOX5AP, FLAP
Database cross-references and differences (RAF-indexed):
- Uniprot P20292 (0-End)
- modified residue (0)
- modified residue (88)
- modified residue (124)
- engineered (147)
Domains in SCOP 1.75: d2q7rf1 - Heterogens: 3CS
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2q7rA (A:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rA (A:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2q7rB (B:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rB (B:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyia
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2q7rC (C:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rC (C:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiat
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2q7rD (D:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rD (D:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyia
- Chain 'E':
Sequence, based on SEQRES records: (download)
>2q7rE (E:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rE (E:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffg
- Chain 'F':
Sequence, based on SEQRES records: (download)
>2q7rF (F:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiatisttisplllip
Sequence, based on observed residues (ATOM records): (download)
>2q7rF (F:)
mdqetvgnvvllaivtlisvvqngffahkvehesrtqngrsfqrtgtlafervytanqnc
vdayptflavlwsagllcsqvpaafaglmylfvrqkyfvgylgertqstpgyifgkriil
flflmsvagifnyylifffgsdfenyiat