PDB entry 2q7l

View 2q7l on RCSB PDB site
Description: The Androgen Receptor Prostate Cancer Mutant H874Y Ligand Binding Domain Bound with Testosterone and a TIF2 box3 Coactivator Peptide 740-753
Class: Hormone
Keywords: androgen receptor prostate cancer mutant H874Y ligand binding domain, testosterone, TIF2 boxIII coactivator peptide, Hormone
Deposited on 2007-06-07, released 2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-05-08, with a file datestamp of 2013-05-03.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: 0.184
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Androgen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: AR, DHTR, NR3C4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10275 (Start-256)
      • engineered (211)
    Domains in SCOPe 2.08: d2q7la_
  • Chain 'B':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: TES, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2q7lA (A:)
hiegyecqpiflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakal
pgfrnlhvddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmys
qcvrmrhlsqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldrii
ackrknptscsrrfyqltklldsvqpiarelyqftfdllikshmvsvdfpemmaeiisvq
vpkilsgkvkpiyfhtq

    Sequence, based on observed residues (ATOM records): (download) 
    >2q7lA (A:)
piflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhv
ddqmaviqyswmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhl
sqefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiarknptsc
srrfyqltklldsvqpiarelyqftfdllikshmvsvdfpemmaeiisvqvpkilsgkvk
piyfhtq

  • Chain 'B':
    No sequence available.