PDB entry 2q72

View 2q72 on RCSB PDB site
Description: Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine
Class: transport protein
Keywords: membrane protein, neurotransmitter sodium symporter, occluded, tricyclic antidepressant, TRANSPORT PROTEIN
Deposited on 2007-06-05, released 2007-08-21
The last revision prior to the SCOP 1.75 freeze date was dated 2008-01-08, with a file datestamp of 2008-01-04.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.203
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transporter
    Species: Aquifex aeolicus
    Gene: snf
    Database cross-references and differences (RAF-indexed):
    • Uniprot O67854 (Start-512)
      • cloning artifact (513-515)
    Domains in SCOP 1.75: d2q72a1
  • Heterogens: BOG, NA, LEU, IXX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2q72A (A:)
    mevkrehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmw
    iewamgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfai
    kflvglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinv
    silirgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkd
    pgvwiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisip
    aavaffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaim
    qpmiafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffgltel
    iiffwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeeth
    wtvwitrfyiiglflfltflvflaerrrnhesagtlvpr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2q72A (A:)
    krehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiew
    amgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikfl
    vglvpeppptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilir
    giskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwi
    aavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaf
    fgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmia
    fledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffw
    ifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwi
    trfyiiglflfltflvflaerrrnhesagtl