PDB entry 2pzf

View 2pzf on RCSB PDB site
Description: Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer with delta F508
Class: hydrolase
Keywords: NBD, ABC transporter, CFTR, F508, HYDROLASE
Deposited on 2007-05-18, released 2007-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (1-18)
      • expression tag (0)
    • Uniprot P13569 (19-227)
      • variant (52)
    Domains in SCOPe 2.08: d2pzfa1, d2pzfa2
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (Start-18)
    • Uniprot P13569 (19-End)
      • variant (52)
    Domains in SCOPe 2.08: d2pzfb_
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2pzfA (A:)
    sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
    segkikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdn
    ivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmank
    trilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pzfA (A:)
    sltttevvmenvtafwggtpvlkdinfkiergqllavagstgagktsllmmimgelepse
    gkikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdniv
    lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
    ilvtskmehlkkadkililhegssyfygtfselqnldfssklmg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2pzfB (B:)
    sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
    segkikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdn
    ivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmank
    trilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pzfB (B:)
    tttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelepse
    gkikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdniv
    lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
    ilvtskmehlkkadkililhegssyfygtfselqnl