PDB entry 2pz5

View 2pz5 on RCSB PDB site
Description: Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, transferase
Deposited on 2007-05-17, released 2007-09-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-02-22, with a file datestamp of 2012-02-17.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.214
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (104)
    Domains in SCOPe 2.06: d2pz5a_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (104)
    Domains in SCOPe 2.06: d2pz5b_
  • Heterogens: SO4, MG, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2pz5A (A:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniitllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pz5A (A:)
    lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlvs
    ememmkmigkhkniitllgactqdgplyviveyaskgnlreylrarrpeeqmtfkdlvsc
    tyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngrlp
    vkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpa
    nctnelymmmrdcwhavpsqrptfkqlvedldriltlttn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2pz5B (B:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniitllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pz5B (B:)
    lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlvs
    ememmkmigkhkniitllgactqdgplyviveyaskgnlreylrarrppeqmtfkdlvsc
    tyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngrlp
    vkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpa
    nctnelymmmrdcwhavpsqrptfkqlvedldriltlttn