PDB entry 2pxc

View 2pxc on RCSB PDB site
Description: Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAM and GTPA
Class: transferase
Keywords: Murray Valley Encephalitis Virus, Methyltransferase, SAM, GTPA, G3A, Structural Genomics, Oxford Protein Production Facility, OPPF, TRANSFERASE
Deposited on 2007-05-14, released 2007-05-29
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.205
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)]
    Species: Murray valley encephalitis virus (strain MVE-1-51) [TaxId:301478]
    Gene: NS5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2pxca_
  • Heterogens: SAM, G3A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pxcA (A:)
graggrtlgeqwkeklnamgkeeffsyrkeailevdrtearrarregnkvgghpvsrgta
klrwlverrfvqpigkvvdlgcgrggwsyyaatmknvqevrgytkggpgheepmlmqsyg
wnivtmksgvdvfykpseisdtllcdigesspsaeieeqrtlrilemvsdwlsrgpkefc
ikilcpympkviekleslqrrfggglvrvplsrnsnhemywvsgasgnivhavnmtsqvl
igrmdkkiwkgpkyeedvnlgsgtravgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2pxcA (A:)
grtlgeqwkeklnamgkeeffsyrkeailevdrtearrarregnkvgghpvsrgtaklrw
lverrfvqpigkvvdlgcgrggwsyyaatmknvqevrgytkggpgheepmlmqsygwniv
tmksgvdvfykpseisdtllcdigesspsaeieeqrtlrilemvsdwlsrgpkefcikil
cpympkviekleslqrrfggglvrvplsrnsnhemywvsgasgnivhavnmtsqvligrm
dkkiwkgpkyeedvnlgsgtrav