PDB entry 2pvw

View 2pvw on RCSB PDB site
Description: A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with 2-(phosphonomethyl)pentanedioic acid (2-PMPA)
Class: Hydrolase
Keywords: prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase II; Naaladase; 2-(phosphonomethyl)pentanedioic acid; 2-(PMPA), Hydrolase
Deposited on 2007-05-10, released 2007-05-22
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.183
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glutamate carboxypeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FOLH1, FOLH, NAALAD1, PSM, PSMA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2pvwa1, d2pvwa2, d2pvwa3
  • Heterogens: NAG, ZN, CA, CL, G88, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pvwA (A:)
rskssneatnitpkhnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwk
efgldsvelahydvllsypnkthpnyisiinedgneifntslfeppppgyenvsdivppf
safspqgmpegdlvyvnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlag
akgvilysdpadyfapgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrr
giaeavglpsipvhpigyydaqkllekmggsappdsswrgslkvpynvgpgftgnfstqk
vkmhihstnevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrs
fgtlkkegwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnyt
lrvdctplmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndf
evffqrlgiasgrarytknwetnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrg
gmvfelansivlpfdcrdyavvlrkyadkiysismkhpqemktysvsfdslfsavknfte
iaskfserlqdfdksnpivlrmmndqlmflerafidplglpdrpfyrhviyapsshnkya
gesfpgiydalfdieskvdpskawgevkrqiyvaaftvqaaaetlseva

    Sequence, based on observed residues (ATOM records): (download) 
    >2pvwA (A:)
hnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahydv
llsypnkthpnyisiinedgneifntslfeppppgyenvsdivppfsafspqgmpegdlv
yvnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlagakgvilysdpadyf
apgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrrgiaeavglpsipvh
pigyydaqkllekmggsappdsswrgslkvpynvgpgftgnfstqkvkmhihstnevtri
ynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkkegwrprrt
ilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctplmyslvh
nltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrlgiasgra
rytknnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfelansivlpfdcr
dyavvlrkyadkiysismkhpqemktysvsfdslfsavknfteiaskfserlqdfsnpiv
lrmmndqlmflerafidplglpdrpfyrhviyapsshnkyagesfpgiydalfdieskvd
pskawgevkrqiyvaaftvqaaaetlseva