PDB entry 2prm

View 2prm on RCSB PDB site
Description: The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Class: oxidoreductase
Keywords: protein inhibitor complex, OXIDOREDUCTASE
Deposited on 2007-05-04, released 2008-05-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2008-12-23, with a file datestamp of 2009-02-19.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.193
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2prma_
  • Heterogens: FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2prmA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
    npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
    nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
    vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
    svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
    iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
    igadhrr