PDB entry 2pjt

View 2pjt on RCSB PDB site
Description: Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344
Class: hydrolase
Keywords: MMPS, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, HYDROXAMATE, HYDROPHOBIC S1',P1' GROUP, Calcium, Collagen degradation, Disease mutation, Extracellular matrix, Glycoprotein, Metal-binding, Polymorphism, Secreted, Zymogen
Deposited on 2007-04-16, released 2008-04-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.212
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2pjta_
  • Chain 'B':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2pjtb_
  • Chain 'C':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2pjtc_
  • Chain 'D':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2pjtd_
  • Heterogens: ZN, CA, 347, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pjtA (A:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp

    Sequence, based on observed residues (ATOM records): (download) 
    >2pjtA (A:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytythfmlpdddvqgiqslygp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2pjtB (B:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp

    Sequence, based on observed residues (ATOM records): (download) 
    >2pjtB (B:)
ynvfptlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadim
isfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahef
ghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2pjtC (C:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp

    Sequence, based on observed residues (ATOM records): (download) 
    >2pjtC (C:)
ynvftlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadimi
sfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahefg
hslgldhskdpgalmfpiytytfmlpdddvqgiqslygp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2pjtD (D:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygp

    Sequence, based on observed residues (ATOM records): (download) 
    >2pjtD (D:)
ynvfptlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadim
isfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahef
ghslgldhskdpgalmfpiytythfmlpdddvqgiqslygp