PDB entry 2ph9

View 2ph9 on RCSB PDB site
Description: Galanthamine bound to an ACh-binding Protein
Class: choline-binding protein
Keywords: non-competitive inhibitors, nicotinic acetylcholine receptor, acetylcholine-binding protein, benzodiazepine, galanthamine, CHOLINE-BINDING PROTEIN
Deposited on 2007-04-10, released 2007-07-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.88 Å
R-factor: 0.207
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: synthetic gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • cloning artifact (3-8)
    Domains in SCOPe 2.06: d2ph9a1, d2ph9a2
  • Chain 'B':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: synthetic gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • cloning artifact (1-8)
    Domains in SCOPe 2.06: d2ph9b1, d2ph9b2
  • Chain 'C':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: synthetic gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • cloning artifact (3-8)
    Domains in SCOPe 2.06: d2ph9c1, d2ph9c2
  • Chain 'D':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: synthetic gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • cloning artifact (3-8)
    Domains in SCOPe 2.06: d2ph9d1, d2ph9d2
  • Chain 'E':
    Compound: Soluble acetylcholine receptor
    Species: Aplysia californica [TaxId:6500]
    Gene: synthetic gene
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8WSF8 (9-End)
      • cloning artifact (4-8)
    Domains in SCOPe 2.06: d2ph9e1, d2ph9e2
  • Heterogens: GNT, PG4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ph9A (A:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ph9A (A:)
ddddklhsqanlmrlksdlfnrsypgptkddpltvtlgftlqdivkadsstnevdlvyye
qqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvm
fipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyei
lsatqtrqvqhysccpepyidvnlvvkfrerra

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ph9B (B:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ph9B (B:)
ykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevdl
vyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthd
gsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyass
kyeilsatqtrqvqhysccpepyidvnlvvkfrerr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ph9C (C:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ph9C (C:)
ddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevdlvy
yeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgs
vmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyassky
eilsatqtrqvqhysccpepyidvnlvvkfrerr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ph9D (D:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ph9D (D:)
ddddklhsqanlmrlksdlfnrspypgptkddpltvtlgftlqdivkadsstnevdlvyy
eqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsv
mfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskye
ilsatqtrqvqhysccpepyidvnlvvkfrerr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2ph9E (E:)
dykddddklhsqanlmrlksdlfnrspmypgptkddpltvtlgftlqdivkadsstnevd
lvyyeqqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvth
dgsvmfipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyas
skyeilsatqtrqvqhysccpepyidvnlvvkfrerragngffrnlfdsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2ph9E (E:)
dddklhsqanlmrlksdlfnrsmypgptkddpltvtlgftlqdivkadsstnevdlvyye
qqrwklnslmwdpneygnitdfrtsaadiwtpditaysstrpvqvlspqiavvthdgsvm
fipaqrlsfmcdptgvdseegatcavkfgswvysgfeidlktdtdqvdlssyyasskyei
lsatqtrqvqhysccpepyidvnlvvkfrerr