SCOPe 2.08: Structural Classification of Proteins

PDB entry 2pg5

View 2pg5 on RCSB PDB site
Description: Crystal Structure of Human Microsomal P450 2A6 N297Q
Class: oxidoreductase
Keywords: CYP2A6, P450 2A6, P450, Monooxygenases, drug metabolizing enzyme, heme, mutant, indole, oxidoreductase
Deposited on 2007-04-06, released 2007-07-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Cytochrome P450 2A6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2A6
Database cross-references and differences (RAF-indexed):
- Uniprot P11509 (Start-471)
  - variant (137)
  - engineered (274)
Domains in SCOPe 2.08: d2pg5a_
Chain 'B':
Compound: Cytochrome P450 2A6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2A6
Database cross-references and differences (RAF-indexed):
- Uniprot P11509 (Start-471)
  - variant (137)
  - engineered (274)
  - expression tag (472)
Domains in SCOPe 2.08: d2pg5b1, d2pg5b2
Chain 'C':
Compound: Cytochrome P450 2A6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2A6
Database cross-references and differences (RAF-indexed):
- Uniprot P11509 (Start-471)
  - variant (137)
  - engineered (274)
Domains in SCOPe 2.08: d2pg5c_
Chain 'D':
Compound: Cytochrome P450 2A6
Species: Homo sapiens [TaxId:9606]
Gene: CYP2A6
Database cross-references and differences (RAF-indexed):
- Uniprot P11509 (Start-471)
  - variant (137)
  - engineered (274)
Domains in SCOPe 2.08: d2pg5d_
Heterogens: HEM, EDO, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2pg5A (A:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

Sequence, based on observed residues (ATOM records): (download)

>2pg5A (A:)
gklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavrea
lvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriq
eeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifq
ftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfids
flirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpeveakvhee
idrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgte
vypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelf
lffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr

Chain 'B':
Sequence, based on SEQRES records: (download)

>2pg5B (B:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

Sequence, based on observed residues (ATOM records): (download)

>2pg5B (B:)
klppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavreal
vdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriqe
eagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifqf
tststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfidsf
lirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpeveakvheei
drvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgtev
ypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelfl
ffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprh

Chain 'C':
Sequence, based on SEQRES records: (download)

>2pg5C (C:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

Sequence, based on observed residues (ATOM records): (download)

>2pg5C (C:)
klppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavreal
vdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriqe
eagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifqf
tststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfidsf
lirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpeveakvheei
drvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgtev
ypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelfl
ffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr

Chain 'D':
Sequence, based on SEQRES records: (download)

>2pg5D (D:)
makktsskgklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlc
ghdavrealvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgk
rgieeriqeeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsll
rmmlgifqftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpn
sprdfidsflirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpe
veakvheeidrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrd
fflpkgtevypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfge
glarmelflffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflprhhhh

Sequence, based on observed residues (ATOM records): (download)

>2pg5D (D:)
gklppgptplpfignylqlnteqmynslmkiserygpvftihlgprrvvvlcghdavrea
lvdqaeefsgrgeqatfdwvfkgygvvfsngerakqlrrfsiatlrdfgvgkrgieeriq
eeagflidalrgtgganidptfflsrtvsnvissivfgdrfdykdkeflsllrmmlgifq
ftststgqlyemfssvmkhlpgpqqqafqllqgledfiakkvehnqrtldpnsprdfids
flirmqeeeknpntefylknlvmttlqlfiggtetvsttlrygflllmkhpeveakvhee
idrvigknrqpkfedrakmpymeaviheiqrfgdvipmslarrvkkdtkfrdfflpkgte
vypmlgsvlrdpsffsnpqdfnpqhflnekgqfkksdafvpfsigkrncfgeglarmelf
lffttvmqnfrlkssqspkdidvspkhvgfatiprnytmsflpr