PDB entry 2p66

View 2p66 on RCSB PDB site
Description: Human DNA Polymerase beta complexed with tetrahydrofuran (abasic site) containing DNA
Class: transferase, lyase/DNA
Keywords: DNA Repair, Base Excision Repair, dRP lyase
Deposited on 2007-03-16, released 2007-04-10
The last revision prior to the SCOP 1.73 freeze date was dated 2007-04-10, with a file datestamp of 2007-07-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.217
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase beta
    Species: HOMO SAPIENS
    Gene: POLB
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2p66a1, d2p66a2, d2p66a3
  • Chain 'B':
    Compound: DNA (5'-d(*cp*cp*gp*ap*cp*ap*gp*cp*gp*cp*ap*tp*cp*ap*gp*c)-3')
  • Chain 'C':
    Compound: DNA (5'-d(*gp*cp*tp*gp*ap*tp*gp*cp*gp*cp*c)-3')
  • Chain 'D':
    Compound: DNA (5'-d(p*(3dr)p*gp*tp*cp*gp*g)-3')
  • Heterogens: NA, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2p66A (A:)
    mskrkapqetlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeak
    klpgvgtkiaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegik
    tledlrknedklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgs
    frrgaessgdmdvllthpsftsestkqpkllhqvveqlqkvhfitdtlskgetkfmgvcq
    lpskndekeyphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirp
    lgvtgvageplpvdsekdifdyiqwkyrepkdrse
    

    Sequence, based on observed residues (ATOM records): (download)
    >2p66A (A:)
    pqetlnggitdmltelanfeknvsqaihkynayrkaasviakyphkiksgaeakklpgvg
    tkiaekideflatgklrklekirqddtsssinfltrvsgigpsaarkfvdegiktledlr
    knedklnhhqriglkyfgdfekripreemlqmqdivlnevkkvdseyiatvcgsfrrgae
    ssgdmdvllthpsftsespkllhqvveqlqkvhfitdtlskgetkfmgvcqlpskndeke
    yphrridirlipkdqyycgvlyftgsdifnknmrahalekgftineytirplgvtgvage
    plpvdsekdifdyiqwkyrepkdrse
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.