PDB entry 2p3u

View 2p3u on RCSB PDB site
Description: Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}
Class: blood clotting
Keywords: protein inhibitor complex, coagulation cofactor, protease, BLOOD CLOTTING
Deposited on 2007-03-09, released 2007-09-11
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.62 Å
R-factor: 0.192
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2p3ua_
  • Chain 'B':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2p3ub_
  • Heterogens: CA, 663, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2p3uA (A:)
    klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle
    

    Sequence, based on observed residues (ATOM records): (download)
    >2p3uA (A:)
    klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2p3uB (B:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmk