PDB entry 2p2i

View 2p2i on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, KDR, Transferase
Deposited on 2007-03-07, released 2007-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-16, with a file datestamp of 2017-08-11.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (2)
      • engineered (125)
      • cloning artifact (307)
      • expression tag (308-313)
    • Uniprot P35968 (125-306)
    Domains in SCOPe 2.08: d2p2ia2, d2p2ia3
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2p2ib_
  • Heterogens: 608, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2p2iA (A:)
    ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
    thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
    fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
    cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
    pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
    qanaqqdrhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2p2iA (A:)
    aerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlthsehralm
    selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykvape
    dlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglalpl
    kwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapd
    yttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2p2iB (B:)
    ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
    thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
    fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
    cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
    pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
    qanaqqdrhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2p2iB (B:)
    lpydaskwefprdrlklgkplgrgqvieadafgidktatcrtvavkmlthsehralmsel
    kilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykfltlehl
    icysfqvakgmeflasrkcihrdlaarnillseknvvkicdfplkwmapetifdrvytiq
    sdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhg
    epsqrptfselvehlgnllqana