PDB entry 2p1l

View 2p1l on RCSB PDB site
Description: Structure of the Bcl-XL:Beclin 1 complex
Class: apoptosis
Keywords: Apoptosis; autophagy; beclin; BH3 domain; Bcl
Deposited on 2007-03-05, released 2007-03-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.226
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2p1la_
  • Chain 'B':
    Compound: Beclin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BECN1, GT197
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14457 (2-End)
      • cloning artifact (0-1)
  • Chain 'C':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2p1lc_
  • Chain 'D':
    Compound: Beclin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BECN1, GT197
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14457 (2-End)
      • cloning artifact (0-1)
  • Chain 'E':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2p1le_
  • Chain 'F':
    Compound: Beclin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BECN1, GT197
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14457 (2-End)
      • cloning artifact (0-1)
  • Chain 'G':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2L1, BCL2L, BCLX
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2p1lg_
  • Chain 'H':
    Compound: Beclin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BECN1, GT197
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14457 (2-End)
      • cloning artifact (0-1)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2p1lA (A:)
msqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >2p1lA (A:)
sqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpg
tayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndh
lepwiqenggwdtfvelygnn

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2p1lC (C:)
msqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >2p1lC (C:)
sqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpg
tayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndh
lepwiqenggwdtfvelygnn

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2p1lE (E:)
msqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >2p1lE (E:)
sqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpg
tayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndh
lepwiqenggwdtfvelygnn

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2p1lG (G:)
msqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitp
gtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylnd
hlepwiqenggwdtfvelygnnaaaesrkgqer

    Sequence, based on observed residues (ATOM records): (download) 
    >2p1lG (G:)
sqsnrelvvdflsyklsqkgyswsqmaavkqalreagdefelryrrafsdltsqlhitpg
tayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndh
lepwiqenggwdtfvelygnn

  • Chain 'H':
    No sequence available.