PDB entry 2ozr

View 2ozr on RCSB PDB site
Description: MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid
Class: hydrolase
Keywords: Crystal Complex Structure, Matrix Metalloproteinase, MMP13 Catalytic Domain, MMP13 Specific Inhibitor, HYDROLASE
Deposited on 2007-02-27, released 2007-07-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.253
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozra_
  • Chain 'B':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrb_
  • Chain 'C':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrc_
  • Chain 'D':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrd_
  • Chain 'E':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozre_
  • Chain 'F':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrf_
  • Chain 'G':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrg_
  • Chain 'H':
    Compound: collagenase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2ozrh_
  • Heterogens: ZN, CA, GG1, HAE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ozrA (A:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrA (A:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ozrB (B:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrB (B:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ozrC (C:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrC (C:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ozrD (D:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrD (D:)
nvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadim
isfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahef
ghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2ozrE (E:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrE (E:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgfmlpdddvqgiqslygpgd

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2ozrF (F:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrF (F:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2ozrG (G:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrG (G:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpg

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2ozrH (H:)
masynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgi
adimisfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflva
ahefghslgldhskdpgalmfpiytytgkshfmlpdddvqgiqslygpgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozrH (H:)
ynvfprtlkwskmnltyrivnytpdmthsevekafkkafkvwsdvtplnftrlhdgiadi
misfgikehgdfypfdgpsgllahafppgpnyggdahfdddetwtssskgynlflvaahe
fghslgldhskdpgalmfpiytytgfmlpdddvqgiqslygpg