PDB entry 2ozl

View 2ozl on RCSB PDB site
Description: Human pyruvate dehydrogenase S264E variant
Class: oxidoreductase
Keywords: pyruvate_dehydrogenase_complex; human; E1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;, OXIDOREDUCTASE
Deposited on 2007-02-26, released 2007-05-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.186
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component alpha subunit, somatic form
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • engineered (267)
    Domains in SCOPe 2.06: d2ozla1, d2ozla2
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (13-340)
      • expression tag (11-12)
    Domains in SCOPe 2.06: d2ozlb1, d2ozlb2, d2ozlb3
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component alpha subunit, somatic form
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • engineered (267)
    Domains in SCOPe 2.06: d2ozlc2, d2ozlc3
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (13-340)
      • expression tag (11-12)
    Domains in SCOPe 2.06: d2ozld1, d2ozld2, d2ozld3
  • Heterogens: MG, K, TPP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2ozlA (A:)
    mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
    iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
    akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
    eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
    trfaaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmv
    nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
    fksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ozlA (A:)
    sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2ozlB (B:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ozlB (B:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2ozlC (C:)
    mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
    iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
    akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
    eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
    trfaaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmv
    nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
    fksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ozlC (C:)
    sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2ozlD (D:)
    mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
    dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
    pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
    vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
    egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
    dapavrvtgadvpmpyakilednsipqvkdiifaikktlni
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ozlD (D:)
    slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
    mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
    asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
    fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
    tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
    vpmpyakilednsipqvkdiifaikktlni