PDB entry 2ozl

View 2ozl on RCSB PDB site
Description: Human pyruvate dehydrogenase S264E variant
Class: oxidoreductase
Keywords: pyruvate_dehydrogenase_complex; human; E1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;
Deposited on 2007-02-26, released 2007-05-22
The last revision prior to the SCOP 1.75 freeze date was dated 2007-06-05, with a file datestamp of 2007-06-05.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.186
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component alpha subunit, somatic form
    Species: HOMO SAPIENS
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • engineered (267)
    Domains in SCOP 1.75: d2ozla1
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta
    Species: HOMO SAPIENS
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (13-340)
      • his tag (11-12)
    Domains in SCOP 1.75: d2ozlb1, d2ozlb2
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component alpha subunit, somatic form
    Species: HOMO SAPIENS
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (4-364)
      • cloning artifact (3)
      • engineered (267)
    Domains in SCOP 1.75: d2ozlc1
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta
    Species: HOMO SAPIENS
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11177 (13-340)
      • his tag (11-12)
    Domains in SCOP 1.75: d2ozld1, d2ozld2
  • Heterogens: MG, K, TPP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ozlA (A:)
mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
trfaaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmv
nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
fksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozlA (A:)
sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ozlB (B:)
mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
dapavrvtgadvpmpyakilednsipqvkdiifaikktlni

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozlB (B:)
slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
vpmpyakilednsipqvkdiifaikktlni

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ozlC (C:)
mrgsfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqk
iirgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggc
akgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqif
eaynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvrea
trfaaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmv
nsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwik
fksvs

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozlC (C:)
sfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
aaaycrsgkgpilmelqtyryhghemsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
vs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ozlD (D:)
mrgshhhhhhgslqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkyg
dkriidtpisemgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglq
pvpivfrgpngasagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvv
vlenelmygvpfefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlsk
egvecevinmrtirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfl
dapavrvtgadvpmpyakilednsipqvkdiifaikktlni

    Sequence, based on observed residues (ATOM records): (download) 
    >2ozlD (D:)
slqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpise
mgfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpng
asagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvp
fefppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmr
tirpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgad
vpmpyakilednsipqvkdiifaikktlni