PDB entry 2ow2

View 2ow2 on RCSB PDB site
Description: MMP-9 active site mutant with difluoro butanoic acid inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: MATRIX METALLOPROTEINASE, S1-PRIME POCKET, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2007-02-15, released 2007-06-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.215
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB)
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14780 (Start-105)
      • engineered (117)
    • Uniprot P14780 (106-158)
    Domains in SCOPe 2.06: d2ow2a_
  • Chain 'B':
    Compound: Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB)
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14780 (Start-105)
      • engineered (117)
    • Uniprot P14780 (106-158)
    Domains in SCOPe 2.06: d2ow2b_
  • Heterogens: ZN, CA, CL, 8MR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ow2A (A:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfg
halgldhssvpealmypmyrftegpplhkddvngirhly

    Sequence, based on observed residues (ATOM records): (download) 
    >2ow2A (A:)
dlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviqfgv
aehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfghal
gldhssvpealmypmyrftegpplhkddvngirhly

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ow2B (B:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfg
halgldhssvpealmypmyrftegpplhkddvngirhly

    Sequence, based on observed residues (ATOM records): (download) 
    >2ow2B (B:)
lkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviqfgva
ehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfghalg
ldhssvpealmypmyrftegpplhkddvngirhly