PDB entry 2op3

View 2op3 on RCSB PDB site
Description: The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method
Class: hydrolase
Keywords: Cathepsin S, NONpeptidic, Substrate Activity Screening, HYDROLASE
Deposited on 2007-01-26, released 2007-05-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.159
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin S
    Species: Homo sapiens [TaxId:9606]
    Gene: CATHS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2op3a_
  • Chain 'B':
    Compound: cathepsin S
    Species: Homo sapiens [TaxId:9606]
    Gene: CATHS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2op3b_
  • Heterogens: SO4, TF5, PEU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2op3A (A:)
nrilpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcs
tekygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelp
ygredvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngk
eywlvknswghnfgeegyirmarnkgnhcgiasfpsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >2op3A (A:)
lpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcstek
ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
lvknswghnfgeegyirmarnkgnhcgiasfpsypei

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2op3B (B:)
nrilpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcs
tekygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelp
ygredvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngk
eywlvknswghnfgeegyirmarnkgnhcgiasfpsypei

    Sequence, based on observed residues (ATOM records): (download) 
    >2op3B (B:)
lpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcstek
ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
lvknswghnfgeegyirmarnkgnhcgiasfpsypei