PDB entry 2oo8
View 2oo8 on RCSB PDB site
Description: Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors
Class: transferase
Keywords: Kinase, TRANSFERASE
Deposited on
2007-01-25, released
2007-03-20
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.235
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'X':
Compound: Angiopoietin-1 receptor
Species: Homo sapiens [TaxId:9606]
Gene: TEK, TIE2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d2oo8x_ - Heterogens: RAJ, HOH
PDB Chain Sequences:
- Chain 'X':
Sequence, based on SEQRES records: (download)
>2oo8X (X:)
knnpdptiypvldwndikfqdvigegnfgqvlkarikkdglrmdaaikrmkeyaskddhr
dfagelevlcklghhpniinllgacehrgylylaieyaphgnlldflrksrvletdpafa
ianstastlssqqllhfaadvargmdylsqkqfihrdlaarnilvgenyvakiadfglsr
gqevyvkktmgrlpvrwmaieslnysvyttnsdvwsygvllweivslggtpycgmtcael
yeklpqgyrlekplncddevydlmrqcwrekpyerpsfaqilvslnrmleerktyvnttl
yekftyagidcsaeeaa
Sequence, based on observed residues (ATOM records): (download)
>2oo8X (X:)
gqvlkarirmdaaikrmkekddhrdfagelevlcklghhpniinllgacehylaieyaph
gnlldflrksrvletdpafaianstastlssqqllhfaadvargmdylsqkqfihrdlaa
rnilvgenyvakiadfglmgrlpvrwmaieslnysvyttnsdvwsygvllweivslggtp
ycgmtcaelyeklpqgyrlekplncddevydlmrqcwrekpyerpsfaqilvslnrmlee
rktyvnttlyekftyagid