SCOPe 2.07: Structural Classification of Proteins

PDB entry 2onm

View 2onm on RCSB PDB site
Description: Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with NAD+
Class: Oxidoreductase
Keywords: oxidoreductase, ALDH, NAD, Rossmann Fold
Deposited on 2007-01-24, released 2007-03-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.23
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onma_
Chain 'B':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmb_
Chain 'C':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmc_
Chain 'D':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmd_
Chain 'E':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onme_
Chain 'F':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmf_
Chain 'G':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmg_
Chain 'H':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmh_
Chain 'I':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmi_
Chain 'J':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmj_
Chain 'K':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onmk_
Chain 'L':
Compound: Aldehyde dehydrogenase, mitochondrial precursor
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (486)
Domains in SCOPe 2.07: d2onml_
Heterogens: NA, ADP, NAD, EDO, GAI, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2onmA (A:)
saaatqavpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvd
kavkaaraafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylv
dldmvlkclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklg
palatgnvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdk
vaftgsteigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgq
cccagsrtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintg
kqegakllcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgra
nnstyglaaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgey
glqaytkvktvtvkvpqkns