PDB entry 2onl

View 2onl on RCSB PDB site
Description: Crystal Structure of the p38a-MAPKAP kinase 2 Heterodimer
Class: transferase
Keywords: heterodimer, kinase, NLS, NES, docking groove, TRANSFERASE
Deposited on 2007-01-24, released 2007-02-06
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 4 Å
R-factor: 0.315
AEROSPACI score: -0.01 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK14, CSBP, CSBP1, CSBP2, MXI2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2onla1
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK14, CSBP, CSBP1, CSBP2, MXI2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2onlb1
  • Chain 'C':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2onlc1
  • Chain 'D':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2onld1

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2onlA (A:)
gshmlemsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkk
lsrpfqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadln
nivkcqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarh
tddemtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlkl
ilrlvgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsd
kritaaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppld
qeemes

    Sequence, based on observed residues (ATOM records): (download) 
    >2onlA (A:)
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglartrwyrapeim
lnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisses
arnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdp
ddepvadpydqsfesrdllidewksltydevisfvppp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2onlB (B:)
gshmlemsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkk
lsrpfqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadln
nivkcqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarh
tddemtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlkl
ilrlvgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsd
kritaaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppld
qeemes

    Sequence, based on observed residues (ATOM records): (download) 
    >2onlB (B:)
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaratrwyrapei
mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
sarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
pddepvadpydqsfesrdllidewksltydevisfvppp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2onlC (C:)
gshmlemlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqi
kknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqc
phivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeai
qylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapev
lgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsev
seevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvke
emtsalatmrvdyeqikikkiedasnplllkrrkkaraleaaalah

    Sequence, based on observed residues (ATOM records): (download) 
    >2onlC (C:)
fhvksglqikknaiiddykvkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcph
ivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqy
lhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlg
pekydkscdmwslgvimyillcgyppfyefpnpewsevseevkmlirnllkteptqrmti
tefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmrvdyeqikikkie
dasnplllkrrkkaral

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2onlD (D:)
gshmlemlsnsqgqsppvpfpapapppqpptpalphppaqppppppqqfpqfhvksglqi
kknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqc
phivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeai
qylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapev
lgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsev
seevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvke
emtsalatmrvdyeqikikkiedasnplllkrrkkaraleaaalah

    Sequence, based on observed residues (ATOM records): (download) 
    >2onlD (D:)
fhvksglqikknaiiddvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfyefpnpewsevseevkmlirnllkteptqrmtitefm
nhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmrvdyeqikikkiedasn
plllkrrkkaral