PDB entry 2og8

View 2og8 on RCSB PDB site
Description: crystal structure of aminoquinazoline 36 bound to Lck
Class: transferase
Keywords: Lck, Kinase domain
Deposited on 2007-01-05, released 2007-02-27
The last revision prior to the SCOP 1.75 freeze date was dated 2007-02-27, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.247
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase LCK
    Species: HOMO SAPIENS
    Gene: LCK
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2og8a1
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase LCK
    Species: HOMO SAPIENS
    Gene: LCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06239 (1-263)
      • cloning artifact (0)
      • cloning artifact (264)
    Domains in SCOP 1.75: d2og8b1
  • Heterogens: 1N8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2og8A (A:)
dewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkql
qhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafi
eernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtapeainyg
tftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrl
cwkerpedrptfdylrsvledffta

    Sequence, based on observed residues (ATOM records): (download) 
    >2og8A (A:)
ewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlq
hqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafie
ernyihrdlraanilvsdtlsckiadfglpikwtapeainygtftiksdvwsfgilltei
vthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerpedrptfdylrsv
ledfft

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2og8B (B:)
dewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkql
qhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafi
eernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtapeainyg
tftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrl
cwkerpedrptfdylrsvledffta

    Sequence, based on observed residues (ATOM records): (download) 
    >2og8B (B:)
dewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkql
qhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafi
eernyihrdlraanilvsdtlsckiadfglapikwtapeainygtftiksdvwsfgillt
eivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerpedrptfdylr
svledffta