SCOPe 2.06: Structural Classification of Proteins — extended

PDB entry 2oax

View 2oax on RCSB PDB site
Description: Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420
Class: transcription
Keywords: aldosterone; steroid receptor; nuclear receptor; transcription factor; activating mutation, hypertension; antagonist; spironolactone
Deposited on 2006-12-18, released 2007-08-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: 0.24
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxa_
Chain 'B':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxb_
Chain 'C':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxc_
Chain 'D':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxd_
Chain 'E':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxe_
Chain 'F':
Compound: Mineralocorticoid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR3C2, MCR, MLR
Database cross-references and differences (RAF-indexed):
- Uniprot P08235
  - engineered (81)
Domains in SCOPe 2.06: d2oaxf_
Heterogens: SNL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2oaxA (A:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxA (A:)
pvmvleniepeivyagydsdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqit
liqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfv
rlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtwqrfyqltklld
smhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Chain 'B':
Sequence, based on SEQRES records: (download)

>2oaxB (B:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxB (B:)
vmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledq
itliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislq
fvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvqrfyqltklld
smhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Chain 'C':
Sequence, based on SEQRES records: (download)

>2oaxC (C:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxC (C:)
pvmvleniepeivyagydsdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqit
liqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfv
rlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkqrfyqltklld
smhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Chain 'D':
Sequence, based on SEQRES records: (download)

>2oaxD (D:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxD (D:)
pvmvleniepeivyagydsdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqit
liqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfv
rlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvqswqrfyqltkll
dsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Chain 'E':
Sequence, based on SEQRES records: (download)

>2oaxE (E:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxE (E:)
pvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlpled
qitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqisl
qfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvqrfyqltkll
dsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh

Chain 'F':
Sequence, based on SEQRES records: (download)

>2oaxF (F:)
gssraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlp
gfknlpledqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyel
cqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvt
kapnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdql
pkvesgnakplyfhrk

Sequence, based on observed residues (ATOM records): (download)

>2oaxF (F:)
pvmvleniepeivyagydsdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqit
liqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfv
rlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvnnsgqswqrfyql
tklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfh