PDB entry 2o9i

View 2o9i on RCSB PDB site
Description: Crystal Structure of the Human Pregnane X Receptor LBD in complex with an SRC-1 coactivator peptide and T0901317
Class: transcription
Keywords: Nuclear Receptor, Pregnane X Receptor, PXR, T0901317, TRANSCRIPTION
Deposited on 2006-12-13, released 2007-01-30
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.228
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orphan nuclear receptor pxr
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1I2, PXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75469
      • engineered (142)
    Domains in SCOPe 2.01: d2o9ia_
  • Chain 'B':
    Compound: orphan nuclear receptor pxr
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1I2, PXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75469 (0-End)
      • engineered (142)
    Domains in SCOPe 2.01: d2o9ib_
  • Chain 'C':
    Compound: Nuclear Receptor Coactivator 1 isoform 3
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2O9I
  • Chain 'D':
    Compound: Nuclear Receptor Coactivator 1 isoform 3
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2O9I (0-14)
  • Heterogens: 444, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2o9iA (A:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelsqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2o9iA (A:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlsreeaakwsqvrkdlcslkvslq
lrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqis
llkgaafelsqlrfntvfnaetgtwecgrlsycledtaggfqqlllepmlkfhymlkklq
lheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkim
amltelrsinaqhtqrllriqdihpfatplmqelfgitg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2o9iB (B:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelsqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgitgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2o9iB (B:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlsreeaakwsqvrkdlcslkvslq
lrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqis
llkgaafelsqlrfntvfnaetgtwecgrlsycledtaggfqqlllepmlkfhymlkklq
lheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkim
amltelrsinaqhtqrllriqdihpfatplmqelfgitg

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.