PDB entry 2o3e

View 2o3e on RCSB PDB site
Description: Crystal structure of engineered neurolysin with thimet oligopeptidase specificity for neurotensin cleavage site.
Class: hydrolase
Keywords: thermolysin-like domain, substrate-binding channel, HYDROLASE
Deposited on 2006-12-01, released 2007-01-23
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.219
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neurolysin
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Nln
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42676 (Start-677)
      • engineered (469)
      • engineered (498)
    Domains in SCOPe 2.01: d2o3ea_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2o3eA (A:)
mtlgkelasplqamssytaagrnvlrwdlspeqiktrteqliaqtkqvydtvgtialkev
tyenclqvladievtyivertmldfpqhvssdrevraasteadkklsrfdiemsmredvf
qrivhlqetcdlekikpearryleksikmgkrnglhlsehirneiksmkkrmselcidfn
knlneddtslvfskaelgalpddfidslektdedkykvtlkyphyfpvmkkccvpetrrk
memafhtrckqentailqqllplraqvakllgynthadfvlelntakstsrvaaflddls
qklkplgeaerefilslkkkeceergfeydgkinawdlhyymtqteelkysvdqeslkey
fpievvtegllsiyqellglsfeqvpdahvwnksvslytvkdkatgevlgqfyldlypre
gkynhaacfglqpgcllpdgsrmmsvaalvvnfsqpvagrpsllrhdevetyfhefghvm
hqicaqtdfarfsgtnverdfvevpsqmlenwvwdvdslrklskhykdghpitdellekl
vasrlvntglltlrqivlskvdqslhtnatldaaseyakycteilgvaatpgtnmpatfg
hlaggydgqyygylwsevfsmdmfhscfkkegimnpevgmkyrnlilkpggsldgmdmlq
nflqrepnqkaflmsrgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2o3eA (A:)
mssytaagrnvlrwdlspeqiktrteqliaqtkqvydtvgtialkevtyenclqvladie
vtyivertmldfpqhvssdrevraasteadkklsrfdiemsmredvfqrivhlqetcdle
kikpearryleksikmgkrnglhlsehirneiksmkkrmselcidfnknlneddtslvfs
kaelgalpddfidslektdedkykvtlkyphyfpvmkkccvpetrrkmemafhtrckqen
tailqqllplraqvakllgynthadfvlelntakstsrvaaflddlsqklkplgeaeref
ilslkkkeceergfeydgkinawdlhyymtqteelkysvdqeslkeyfpievvtegllsi
yqellglsfeqvpdahvwnksvslytvkdkatgevlgqfyldlypregkynhaacfglqp
gcllpdgsrmmsvaalvvnfsqpvagrpsllrhdevetyfhefghvmhqicaqtdfarfs
gtnverdfvevpsqmlenwvwdvdslrklskhykdghpitdelleklvasrlvntglltl
rqivlskvdqslhtnatldaaseyakycteilgvaatpgtnmpatfghlaggydgqyygy
lwsevfsmdmfhscfkkegimnpevgmkyrnlilkpggsldgmdmlqnflqrepnqkafl
msrgl