PDB entry 2o23

View 2o23 on RCSB PDB site
Description: The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
Class: oxidoreductase
Keywords: HSD17B10, SCHAD, ERAB, Type II HADH, 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase, MHBD, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2006-11-29, released 2006-12-12
The last revision prior to the SCOP 1.73 freeze date was dated 2006-12-12, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: 0.123
AEROSPACI score: 0.71 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HADH2 protein
    Species: HOMO SAPIENS
    Gene: HADH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6IBS9 (Start-262)
      • cloning artifact (263-264)
    Domains in SCOP 1.73: d2o23a1
  • Chain 'B':
    Compound: HADH2 protein
    Species: HOMO SAPIENS
    Gene: HADH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6IBS9 (2-262)
      • cloning artifact (263-264)
    Domains in SCOP 1.73: d2o23b1
  • Heterogens: NAD, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2o23A (A:)
ghmaaacrsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnnc
vfapadvtsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvl
dvnlmgtfnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgm
tlpiardlapigirvmtiapglfgtplltslpekvcnflasqvpfpsrlgdpaeyahlvq
aiienpflngevirldgairmqpgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2o23A (A:)
rsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadv
tsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgt
fnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiard
lapigirvmtiapglfgtpnflasqvpfpsrlgdpaeyahlvqaiienpflngevirldg
airmqpgs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2o23B (B:)
ghmaaacrsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnnc
vfapadvtsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvl
dvnlmgtfnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgm
tlpiardlapigirvmtiapglfgtplltslpekvcnflasqvpfpsrlgdpaeyahlvq
aiienpflngevirldgairmqpgs

    Sequence, based on observed residues (ATOM records): (download) 
    >2o23B (B:)
maaacrsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvf
apadvtsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldv
nlmgtfnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtl
piardlapigirvmtiapglfgtpllnflasqvpfpsrlgdpaeyahlvqaiienpflng
evirldgairmqpgs