PDB entry 2nyl

View 2nyl on RCSB PDB site
Description: Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated
Class: hydrolase/hydrolase inhibitor
Keywords: HEAT repeat, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2006-11-20, released 2006-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nyla1
  • Chain 'B':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nylb1
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nylc1
  • Chain 'D':
    Compound: Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nyld1
  • Chain 'E':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nyle1
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2nylf1
  • Chain 'G':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Chain 'H':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylA (A:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylB (B:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylC (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylD (D:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylE (E:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nylF (F:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpapr

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.