PDB entry 2nx1

View 2nx1 on RCSB PDB site
Description: Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase
Class: transferase
Keywords: kdo, kdo8p, kdo8ps, pep, a5p, rp5, transferase
Deposited on 2006-11-16, released 2007-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Aquifex aeolicus [TaxId:63363]
    Gene: kdsA
    Database cross-references and differences (RAF-indexed):
    • Uniprot O66496
      • engineered (10)
    Domains in SCOPe 2.08: d2nx1a_
  • Chain 'B':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Aquifex aeolicus [TaxId:63363]
    Gene: kdsA
    Database cross-references and differences (RAF-indexed):
    • Uniprot O66496
      • engineered (10)
    Domains in SCOPe 2.08: d2nx1b_
  • Heterogens: RP5, PEP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2nx1A (A:)
mekflviagpnaieseelllkvgeeikrlsekfkevefvfkssfdkanrssihsfrghgl
eygvkalrkvkeefglkittdiheswqaepvaevadiiqipaflcrqtdlllaaaktgra
vnvkkgqflapwdtknvveklkfggakeiyltergttfgynnlvvdfrslpimkqwakvi
ydathsvqlpgglgdksggmrefifpliraavavgcdgvfmethpepekalsdastqlpl
sqlegiieaileirevaskyyetipvk

    Sequence, based on observed residues (ATOM records): (download) 
    >2nx1A (A:)
ekflviagpnaieseelllkvgeeikrlsekfkevefvfkssfdkanrssihsfrghgle
ygvkalrkvkeefglkittdiheswqaepvaevadiiqipaflcrqtdlllaaaktgrav
nvkkgqflapwdtknvveklkfggakeiyltergttfgynnlvvdfrslpimkqwakviy
dathsvqlpgglgdksggmrefifpliraavavgcdgvfmethpepekalsdastqlpls
qlegiieaileirevaskyyeti

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2nx1B (B:)
mekflviagpnaieseelllkvgeeikrlsekfkevefvfkssfdkanrssihsfrghgl
eygvkalrkvkeefglkittdiheswqaepvaevadiiqipaflcrqtdlllaaaktgra
vnvkkgqflapwdtknvveklkfggakeiyltergttfgynnlvvdfrslpimkqwakvi
ydathsvqlpgglgdksggmrefifpliraavavgcdgvfmethpepekalsdastqlpl
sqlegiieaileirevaskyyetipvk

    Sequence, based on observed residues (ATOM records): (download) 
    >2nx1B (B:)
kflviagpnaieseelllkvgeeikrlsekfkevefvfkssfdkanrssihsfrghgley
gvkalrkvkeefglkittdiheswqaepvaevadiiqipaflcrqtdlllaaaktgravn
vkkgqflapwdtknvveklkfggakeiyltergttfgynnlvvdfrslpimkqwakviyd
athsvqlpgglgdksggmrefifpliraavavgcdgvfmethpepekalsdastqlplsq
legiieaileirevaskyyeti