PDB entry 2nry

View 2nry on RCSB PDB site
Description: Crystal structure of IRAK-4
Class: transferase
Keywords: kinase, inhibitor, staurosporine, TRANSFERASE
Deposited on 2006-11-02, released 2006-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.212
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191)
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191)
    Domains in SCOPe 2.08: d2nryb_
  • Chain 'C':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191)
    Domains in SCOPe 2.08: d2nryc_
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3 (Start-306)
      • modified residue (191)
    Domains in SCOPe 2.08: d2nryd_
  • Heterogens: STU, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2nryB (B:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nryB (B:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaaitteel
kqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswh
mrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarastvmtsrivgt
taymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektie
dyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2nryC (C:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nryC (C:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkllkqqfdqe
ikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmrckiaq
gaanginflhenhhihrdiksanilldeaftakisdfglarasqtvmtsrivgttaymap
ealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedyidkk
mndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2nryD (D:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nryD (D:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklelkqqfdq
eikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmrckia
qgaanginflhenhhihrdiksanilldeaftakisdfglarasevmtsrivgttaymap
ealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedyidkk
mndadstsveamysvasqclhekknkrpdikkvqqllqemtas