PDB entry 2nru

View 2nru on RCSB PDB site
Description: Crystal structure of IRAK-4
Class: transferase
Keywords: kinase, inhibitor, IRAK, TRANSFERASE
Deposited on 2006-11-02, released 2006-12-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.237
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191-192)
    Domains in SCOPe 2.07: d2nrua_
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191-192)
    Domains in SCOPe 2.07: d2nrub_
  • Chain 'C':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191-192)
    Domains in SCOPe 2.07: d2nruc_
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (191-192)
    Domains in SCOPe 2.07: d2nrud_
  • Heterogens: SO4, T12, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2nruA (A:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nruA (A:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2nruB (B:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nruB (B:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2nruC (C:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nruC (C:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2nruD (D:)
enkslevsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavk
klaamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldr
lscldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfgla
rasekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrep
qllldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqql
lqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2nruD (D:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqtv
mtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeei
edeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt