PDB entry 2nqd

View 2nqd on RCSB PDB site
Description: Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L
Class: hydrolase inhibitor/hydrolase
Keywords: chagasin-cathepsin L complex, three prong inhibition mode, HYDROLASE INHIBITOR-HYDROLASE COMPLEX
Deposited on 2006-10-31, released 2007-07-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.15
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Chagasin
    Species: Trypanosoma cruzi [TaxId:5693]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2nqda_
  • Chain 'B':
    Compound: Cathepsin L
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07711 (1-220)
      • engineered (25)
    Domains in SCOPe 2.06: d2nqdb_
  • Heterogens: NA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nqdA (A:)
    shkvtkahngatltvavgelveiqlpsnpttgfawyfeggtkespnesmftvenkyfppd
    skllgaggtehfhvtvkaagthavnltymrpwtgpshdserftvylkan
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nqdB (B:)
    eaprsvdwrekgyvtpvknqgqcgsawafsatgalegqmfrktgrlislseqnlvdcsgp
    qgnegcngglmdyafqyvqdnggldseesypyeateesckynpkysvandtgfvdipkqe
    kalmkavatvgpisvaidaghesflfykegiyfepdcssedmdhgvlvvgygfestesdn
    nkywlvknswgeewgmggyvkmakdrrnhcgiasaasyptv