PDB entry 2npp

View 2npp on RCSB PDB site
Description: Structure of the Protein Phosphatase 2A Holoenzyme
Class: hydrolase/hydrolase inhibitor
Keywords: HEAT repeat, SIGNALING PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2006-10-28, released 2006-12-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: 0.255
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppa1
  • Chain 'B':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppb1
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppc1
  • Chain 'D':
    Compound: Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppd1
  • Chain 'E':
    Compound: serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R5C, KIAA0044
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppe1
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2nppf1
  • Chain 'X':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Chain 'Y':
    Compound: microcystin LR
    Species: Cyanobacteria, synthetic [TaxId:1117]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: MN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2nppA (A:)
maaadgddslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiy
dedevllalaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehs
psdleahfvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpm
vrraaasklgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedl
ealvmptlrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevra
aashkvkefcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdn
tiehllplflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvr
laiieympllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewaha
tiipkvlamsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnv
akslqkigpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppA (A:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2nppB (B:)
mltcnkagsrmvvdaansngpfqpvvllhirdvppadqeklfiqklrqccvlfdfvsdpl
sdlkwkevkraalsemveyithnrnvitepiypevvhmfavnmfrtlppssnptgaefdp
eedeptleaawphlqlvyefflrflespdfqpniakkyidqkfvlqllelfdsedprerd
flkttlhriygkflglrayirkqinnifyrfiyetehhngiaelleilgsiingfalplk
eehkifllkvllplhkvkslsvyhpqlaycvvqflekdstltepvvmallkywpkthspk
evmflneleeildviepsefvkimeplfrqlakcvssphfqvaeralyywnneyimslis
dnaakilpimfpslyrnskthwnktihgliynalklfmemnqklfddctqqfkaeklkek
lkmkereeawvkienlakanpqvlkkrit

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppB (B:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2nppC (C:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephv
trrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppC (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephvt
rrtpdyfl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2nppD (D:)
maaadgddslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiy
dedevllalaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehs
psdleahfvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpm
vrraaasklgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedl
ealvmptlrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevra
aashkvkefcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdn
tiehllplflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvr
laiieympllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewaha
tiipkvlamsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnv
akslqkigpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppD (D:)
dslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2nppE (E:)
mltcnkagsrmvvdaansngpfqpvvllhirdvppadqeklfiqklrqccvlfdfvsdpl
sdlkwkevkraalsemveyithnrnvitepiypevvhmfavnmfrtlppssnptgaefdp
eedeptleaawphlqlvyefflrflespdfqpniakkyidqkfvlqllelfdsedprerd
flkttlhriygkflglrayirkqinnifyrfiyetehhngiaelleilgsiingfalplk
eehkifllkvllplhkvkslsvyhpqlaycvvqflekdstltepvvmallkywpkthspk
evmflneleeildviepsefvkimeplfrqlakcvssphfqvaeralyywnneyimslis
dnaakilpimfpslyrnskthwnktihgliynalklfmemnqklfddctqqfkaeklkek
lkmkereeawvkienlakanpqvlkkrit

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppE (E:)
qeklfiqklrqccvlfdfvsdplsdlkwkevkraalsemveyithnrnvitepiypevvh
mfavnmfrtlppssnptgaefdpeedeptleaawphlqlvyefflrflespdfqpniakk
yidqkfvlqllelfdsedprerdflkttlhriygkflglrayirkqinnifyrfiyeteh
hngiaelleilgsiingfalplkeehkifllkvllplhkvkslsvyhpqlaycvvqflek
dstltepvvmallkywpkthspkevmflneleeildviepsefvkimeplfrqlakcvss
phfqvaeralyywnneyimslisdnaakilpimfpslyrnskthwnktihgliynalklf
memnqklfddctqqfkaeklkeklkmke

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2nppF (F:)
mdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhg
qfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhes
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhi
raldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsra
hqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephv
trrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >2nppF (F:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgephvt
rrtpdyfl

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.