PDB entry 2nof

View 2nof on RCSB PDB site
Description: Structure of Q315F human 8-oxoguanine glycosylase proximal crosslink to 8-oxoguanine DNA
Class: Hydrolase, Lyase/DNA
Keywords: N-glycosylase/DNA lyase, DNA repair, 8-oxoguanine, Hydrolase, Lyase-DNA COMPLEX
Deposited on 2006-10-25, released 2006-11-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-18, with a file datestamp of 2017-10-13.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: N-glycosylase/DNA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: OGG1, MMH, MUTM, OGH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15527 (9-End)
      • cloning artifact (6-8)
      • engineered (146)
      • engineered (312)
    Domains in SCOPe 2.08: d2nofa1, d2nofa2, d2nofa3
  • Chain 'B':
    Compound: 5'-d(*gp*gp*tp*ap*gp*ap*cp*cp*tp*gp*gp*ap*cp*gp*c)-3'
  • Chain 'C':
    Compound: 5'-d(*gp*cp*gp*tp*c*cp*ap*(g42)p*gp*tp*cp*tp*ap*cp*c)-3'
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2nofA (A:)
amadigsefghrtlastpalwasipcprselrldlvlpsgqsfrwreqspahwsgvladq
vwtltqteeqlhctvyrgdksqasrptpdeleavrkyfqldvtlaqlyhhwgsvdshfqe
vaqkfqgvrllrqdpieclfsficsscnniaritgmverlcqafgprliqlddvtyhgfp
slqalagpeveahlrklglgyraryvsasaraileeqgglawlqqlressyeeahkalci
lpgvgtkvadciclmaldkpqavpvdvhmwhiaqrdyswhpttsqakgpspqtnkelgnf
frslwgpyagwafavlfsadlrqsr

    Sequence, based on observed residues (ATOM records): (download) 
    >2nofA (A:)
sefghrtlastpalwasipcprselrldlvlpsgqsfrwreqspahwsgvladqvwtltq
teeqlhctvyrsqasrptpdeleavrkyfqldvtlaqlyhhwgsvdshfqevaqkfqgvr
llrqdpieclfsficsscnniaritgmverlcqafgprliqlddvtyhgfpslqalagpe
veahlrklglgyraryvsasaraileeqgglawlqqlressyeeahkalcilpgvgtkva
dciclmaldkpqavpvdvhmwhiaqrdyswhpttsqakgpspqtnkelgnffrslwgpya
gwafavlfsadl

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.