PDB entry 2no9

View 2no9 on RCSB PDB site
Description: The structure of deoxycytidine kinase complexed with troxacitabine and ADP.
Class: transferase
Keywords: dCK, troxacitabine, human deoxycytidine kinase, L-dC, enantiomer, anticancer, TRANSFERASE
Deposited on 2006-10-25, released 2007-02-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.201
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered (64)
      • engineered (78)
      • engineered (165)
    Domains in SCOPe 2.05: d2no9a_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered (64)
      • engineered (78)
      • engineered (165)
    Domains in SCOPe 2.05: d2no9b_
  • Heterogens: ADP, LTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2no9A (A:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2no9A (A:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmsqkng
gnvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifa
snlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeq
gipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkefls
tl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2no9B (B:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2no9B (B:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqnggnvlqmmyekperws
ftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewt
iyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykhe
swllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl