PDB entry 2no6

View 2no6 on RCSB PDB site
Description: C4S dCK variant of dCK in complex with FTC+ADP
Class: transferase
Keywords: dCK, emtricitabine, human deoxycytidine kinase, FTC, enantiomer, antiviral, TRANSFERASE
Deposited on 2006-10-25, released 2007-07-03
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.192
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered (64)
      • engineered (78)
      • engineered (165)
    Domains in SCOPe 2.04: d2no6a_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-279)
      • engineered (64)
      • engineered (78)
      • engineered (165)
    Domains in SCOPe 2.04: d2no6b_
  • Heterogens: ADP, ETV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2no6A (A:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2no6A (A:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmsqkng
gnvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifa
snlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeq
gipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkefls
tl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2no6B (B:)
mgsshhhhhhssglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvni
lkqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtya
clsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2no6B (B:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqggnvlqmmyekperwsf
tfqtyaclsriraqlaslngkldaekpvlffersvysdryifasnlyesesmnetewtiy
qdwhdwmnnqfsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswll
hrtlktnfdylqevpiltldvnedfkkyeslvekvkeflstl