PDB entry 2ngr

View 2ngr on RCSB PDB site
Description: transition state complex for GTP hydrolysis by cdc42: comparisons of the high resolution structures for cdc42 bound to the active and catalytically compromised forms of the cdc42-gap.
Class: hydrolase
Keywords: transition state, g-protein, gap, cdc42, alf3.
Deposited on 1998-07-31, released 1999-01-06
The last revision prior to the SCOP 1.75 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.253
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (GTP binding protein (g25k))
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2ngra_
  • Chain 'B':
    Compound: protein (gtpase activating protein (rhg))
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07960
      • mutation (76)
    Domains in SCOP 1.75: d2ngrb_
  • Heterogens: MG, GDP, AF3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ngrA (A:)
mqtikcvvvgdgavgktcllisyttnkfpseyvptvfdnyavtvmiggepytlglfdtag
qedydrlrplsypqtdvflvcfsvvspssfenvkekwvpeithhcpktpfllvgtqidlr
ddpstieklaknkqkpitpetaeklardlkavkyvecsaltqkglknvfdeailaalepp
epkksrrcvll

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ngrB (B:)
iprqvlkyddflkstqkspatapkpmpprpplpnqqfgvslqhlqeknpeqepipivlre
tvaylqahalttegifarsantqvvrevqqkynmglpvdfdqynelhlpavilktflrel
peplltfdlyphvvgflnidesqrvpatlqvlqtlpeenyqvlrfltaflvqisahsdqn
kmtntnlavvfgpnllwakdaaitlkainpintftkflldhqgelfpspdpsgl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ngrB (B:)
lpnqqfgvslqhlqeknpeqepipivlretvaylqahalttegifarsantqvvrevqqk
ynmglpvdfdqynelhlpavilktflrelpeplltfdlyphvvgflnidesqrvpatlqv
lqtlpeenyqvlrfltaflvqisahsdqnkmtntnlavvfgpnllwakdaaitlkainpi
ntftkflldhqgelfp