PDB entry 2k05

View 2k05 on RCSB PDB site
Description: Structure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7, 12 and 21
Class: cytokine
Keywords: stromal cell derived factor-1, SDF1-alpha, CXCL12, CXCR4, chemokine, sulfotyrosine, locked dimer, Alternative splicing, Chemotaxis, Cytokine, Growth factor, Secreted, G-protein coupled receptor, Glycoprotein, Host-virus interaction, Membrane, Receptor, Sulfation, Transducer, Transmembrane
Deposited on 2008-01-24, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: NMR
Resolution: N/A
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Stromal cell-derived factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CXCL12, SDF1, SDF1A, SDF1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48061
      • engineered (37)
      • engineered (66)
    Domains in SCOPe 2.08: d2k05a_
  • Chain 'B':
    Compound: C-X-C chemokine receptor type 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CXCR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61073
      • engineered (29)
  • Chain 'C':
    Compound: Stromal cell-derived factor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CXCL12, SDF1, SDF1A, SDF1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48061 (2-69)
      • engineered (37)
      • engineered (66)
    Domains in SCOPe 2.08: d2k05c_
  • Chain 'D':
    Compound: C-X-C chemokine receptor type 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CXCR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61073 (2-39)
      • engineered (29)

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2k05A (A:)
    gmkpvslsyrcpcrffeshvaranvkhlkilntpncacqivarlknnnrqvcidpklkwi
    qeylekclnk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2k05A (A:)
    kpvslsyrcpcrffeshvaranvkhlkilntpncacqivarlknnnrqvcidpklkwiqe
    ylekclnk
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2k05C (C:)
    gmkpvslsyrcpcrffeshvaranvkhlkilntpncacqivarlknnnrqvcidpklkwi
    qeylekclnk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2k05C (C:)
    kpvslsyrcpcrffeshvaranvkhlkilntpncacqivarlknnnrqvcidpklkwiqe
    ylekclnk
    

  • Chain 'D':
    No sequence available.