PDB entry 2jfl

View 2jfl on RCSB PDB site
Description: crystal structure of human ste20-like kinase (diphosphorylated form) bound to 5- amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
Class: transferase
Keywords: transferase, serine/threonine-protein kinase, ATP-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine- threonine kinase 2, nucleotide-binding, serine-threonine-protein kinase
Deposited on 2007-02-02, released 2007-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ste20-like serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JFL
      • conflict (29)
    • Uniprot Q9H2G2
    Domains in SCOPe 2.08: d2jfla_
  • Heterogens: DKI, EDO, SCN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2jflA (A:)
mhhhhhhssgvdlgtenlyfqsmkqyehvtrdlnpedfweiigelgdgafgkvykaqnke
tsvlaaakvidtkseeeledymveidilascdhpnivklldafyyennlwiliefcagga
vdavmlelerpltesqiqvvckqtldalnylhdnkiihrdlkagnilftldgdikladfg
vsakntrtiqrrdsfigtpywmapevvmcetskdrpydykadvwslgitliemaeiepph
helnpmrvllkiaksepptlaqpsrwssnfkdflkkcleknvdarwttsqllqhpfvtvd
snkpireliaeakaevteevedgke

    Sequence, based on observed residues (ATOM records): (download) 
    >2jflA (A:)
yehvtrdlnpedfweiigelgdgafgkvykaqnketsvlaaakvidtkseeeledymvei
dilascdhpnivklldafyyennlwiliefcaggavdavmlelerpltesqiqvvckqtl
dalnylhdnkiihrdlkagnilftldgdikladfgvsakntrtiqrrdsfigtpywmape
vvmcetskdrpydykadvwslgitliemaeiepphhelnpmrvllkiaksepptlaqpsr
wssnfkdflkkcleknvdarwttsqllqhpfvtvdsnkpireliaeak